New AI and medical scanning study could end the need for invasive surgery to diagnose endometriosis.

New AI and medical scanning study could end the need for invasive surgery to diagnose endometriosis

March 7, 2022

A new study of women with endometriosis is underway exploring the potential of Artificial Intelligence (AI) and cutting-edge medical scanning techniques to diagnose endometriosis earlier without going through invasive surgery.

The study named DEFEND (Developing an US-MRI-biomarker fusion model for Endometriosis) is now recruiting patients. Researchers are aiming to recruit up to 100 patients at King’s Fertility clinic who are experiencing the condition.

Endometriosis is a common condition affecting one in 10 women in the UK of childbearing age. Women living with endometriosis may have to put up with significant pelvic and abdominal pain during menstruation, painful intercourse and spontaneous pain outside menstruation. In some cases, it can lead to infertility issues and 30-50% of women with infertility also being diagnosed with endometriosis. With March being Endometriosis Action Month, improving diagnosis and care is needed through tangible and collective efforts.

An All Party Parliamentary Group (APPG) Report on Endometriosis revealed that women with endometriosis are facing serious delays to diagnosis with nearly two thirds visiting their GP over 10 times, a quarter visiting doctors in hospitals 10 times or more and over half ending up in A&E due to their pain. According to the report, it takes 8 years on average from the onset of symptoms to receiving a diagnosis, the same length of time as it did a decade ago, highlighting an urgent need for investment in research to drive down this time and ensure appropriate access to care when women need it.

In addition, The Department for Health and Social Care (DHSC) ’Women’s Health – Let’s talk about it’ survey showed that 63% of respondents identified gynaecological conditions as a top priority for action and further research.

Endometriosis is a clinical condition, initially diagnosed based on a collection of symptoms. However, to definitively diagnose endometriosis usually involves invasive surgery called laparoscopy (keyhole surgery into the abdomen under general anaesthetic). Ultrasound and magnetic resonance imaging (MRI) can be used to help diagnose endometriosis. However, ultrasound is not always reliable for all types of endometriosis and MRI is reserved for severe disease where bowel and bladder symptoms are present, added to which there is no single standardised MRI scanning protocol currently provides all the information required for a definitive diagnosis.

The DEFEND study will explore the effectiveness of using 2D and 3D ultrasound and MRI scanning. It aims to create a database of ultrasound and MRI images, along with clinical symptoms and medical history, for women with a diagnosis or symptoms of endometriosis. These images will be analysed to enable the potential development of computer algorithms to read images and harness the power of AI to better diagnose and manage women with endometriosis in the future.

“I’m really excited that the first DEFEND patients have been recruited. Endometriosis is such a poorly diagnosed condition, affecting 10-33% of women of reproductive age in the UK. Despite endometriosis being such a common condition, delayed diagnosis is a significant problem as symptoms often overlap with other conditions and can lead to infertility. Currently, diagnosis using conventional imaging techniques isn’t always possible, with key-hole surgery (known as a laparoscopy) being the present ‘gold standard’ way to reach a definitive diagnosis. However, this is an invasive procedure, meaning that it can either lead to years of uncertainty for those that have endometriosis but are reluctant to have surgery, or unnecessary surgery for those that are eventually shown not to have endometriosis. Our sincere hope is that this study will bring about the development of an algorithm to enable diagnosis through minimally invasive approaches; this would be a huge step forward for women with endometriosis symptoms.”

Chief Investigator Dr Ippokratis Sarris, Consultant in Reproductive Medicine and Director of King’s Fertility

“Living with endometriosis has meant living with debilitating pain, in particular 8-day long excruciatingly painful periods, since I was 15 years old. I have had four surgical laparoscopies to help manage my endometriosis. It’s an honour to be part of a study like this to help other women be diagnosed much sooner, using less invasive techniques. If they knew back then what they know now, my life could be incredibly different. My hope is that in the future women do not have to go through invasive surgeries to have endometriosis diagnosed and receive the support and care they need.”

Jacqui Nix, a 35 year old patient at King’s Fertility clinic living with endometriosis

The study is funded by the National Consortium of Intelligent Medical Imaging (NCIMI) and is being executed by a partnership between King’s Fertility, Perspectum and GE Healthcare.

“This is an important study for NCIMI to be funding because it is working to address an unmet need for many women in the UK who are living with this painful condition. We believe the latest technology in medical scanning, together with developing powerful new algorithms, could be key to unlocking more efficient diagnosis. We’ve brought together a powerful partnership of industry and medical experts to carry out this research. Conditions that only affect women can often get overlooked. We are determined for that not to be the case with endometriosis.”

Dr Mark Beggs, Chief Operating Officer of NCIM

Recruitment of patients to take part in the DEFEND study started in January 2022 and will continue for at least 6 months. Participants will be recruited from those patients on the surgical waiting list at the Gynaecology and Reproductive Medicine Clinic at King’s Fertility.

“I am acutely aware of the detrimental impact this condition has on the lives of so many women of all ages. Practitioners can often dismiss, or even ignore symptoms, leading to significant delays in endometriosis diagnosis. To cope with this debilitating condition women need open access to faster modalities for diagnosis as well as appropriate treatments hallmarked by compassionate care and support. The DEFEND study is an exciting collaboration looking at novel non-invasive imaging modalities to improve diagnoses. We are prioritising using our technologies to provide a rapid alternative diagnostic pathway for women with the objective of significantly reducing the current average waiting time of 8 long years to endometriosis diagnosis and subsequent management and treatment.”

Professor Sally Collins, Clinical Lead for Women’s Health at Perspectum

“Ultrasound is a key tool in the diagnosis of endometriosis, but it’s a very specialised exam. As we move forward with AI, one of our goals will be to move from a more specialised exam to more of a routine type exam, which should hopefully help speed up diagnosis of this painful condition. The benefit of ultrasound in the diagnosis of endometriosis is that it gives you a real-time view of the motion within the tissue and it helps you really understand where the point of pain is. When you utilise that information in combination with the ultrasound image characteristics you can get a more complete evaluation of endometriosis.”

Barbara Del Prince, Director, Global Product and Clinical Management, Women’s Health Ultrasound, GE Healthcare

About the study

The DEFEND study will assess whether using combined imaging methods (from MRI and ultrasound) will be a more suitable option to diagnose endometriosis than the current method of surgical laparoscopy. Surgical laparoscopy is a procedure that allows surgeons to look at the inside of the abdomen and pelvis through a small incision in the abdomen.

Endometriosis develops differently in different women and the study will get a sample of images that represents endometriosis more broadly across the patient population. From the analysis of images collected as part of this study, and combined to create a database, the aim is to develop computer algorithms that can be used to better diagnose endometriosis in the future.

The study is aiming to recruit 100 participants with 39 women consented to take part.

About endometriosis

Endometriosis is a chronic condition where endometrial tissue is found outside the uterine cavity. Each month, this tissue reacts to oestrogen in the same way as the lining of the womb, resulting in the formation of scar tissue and inflammation.

Globally, endometriosis affects 10% of people assigned female at birth of childbearing age which equates to 1.5 million in the UK and 176 million worldwide. This has a massive impact on the UK economy, costing £8.2 billion a year through loss of work, treatment and specialist healthcare costs.

The symptoms of endometriosis vary massively, the most common symptoms include pelvic pain; which can often be worse during a period, to a point where it can impact on normal daily activities, pain during or after sex, pain when passing urine or stools, nausea, constipation or diarrhoea and can also impact fertility with up to 47% of women experiencing infertility, also being diagnosed with endometriosis.